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Published on: April 25, 2016
Basal cortisol in asthmatics on two different doses of fluticasone propionate
Cláudia R de Andrade1, Paulo Augusto M Camargos, Cássio da C Ibiapina
1Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
Objectives:
To evaluate basal plasma cortisol in persistent asthmatics on inhaled fluticasone propionate 200 mcg/day and 300 mcg/day.
Methods:
Asthma diagnosis and classification was based on Global Initiative for Asthma recommendations. Patients aged 11 years old or less received fluticasone propionate 200 mcg/day and those older than 11 years received 300 mcg/day. After 10 weeks of treatment, plasma cortisol levels were monitored to evaluate the hypothalamic-pituitary-adrenal axis.
Results:
Forty-one patients (65.9% males) aged 6 to 18 years old were evaluated. No statistical differences were found between plasma cortisol levels in patients who received 200 mcg/day (n = 13) and those who received 300 mcg/day (n = 28).
Conclusions:
Our results show that low and moderate doses of fluticasone propionate do not cause adrenal suppression.
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