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Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
Published on: February 22, 2019
Studies with a bivalent infectious bronchitis killed virus vaccine
P M Finney1, P G Box, H C Holmes
1Pitman-Moore Ltd., Uxbridge, Middlesex, England.
Avian Pathology : Journal of the W.V.P.A
|July 1, 1990
Summary
A prime-boost vaccination strategy using live and killed infectious bronchitis virus vaccines improved antibody responses against variant strains. This approach effectively protected egg production in challenged laying hens.
Area of Science:
- Veterinary Virology
- Immunology
- Poultry Health
Background:
- Infectious Bronchitis Virus (IBV) poses a significant threat to poultry production.
- Existing vaccines may not provide adequate protection against emerging variant serotypes.
- Optimizing vaccination protocols is crucial for maintaining flock health and productivity.
Purpose of the Study:
- To compare antibody responses in chickens following different infectious bronchitis virus vaccination programs.
- To evaluate the efficacy of a prime-boost vaccination strategy against variant IBV strains.
- To assess the protection of egg production in vaccinated laying hens challenged with IBV.
Main Methods:
- Chickens received primary vaccinations with live IBV strains during rearing.
- Inactivated oil-adjuvanted vaccines (M41, GV101, or bivalent) were administered at 16 weeks.
- Vaccinated laying hens were challenged with virulent D207 serotype IBV strains.
- Haemagglutination inhibition and virus neutralization antibody titers were measured.
Main Results:
- Mass type vaccines alone resulted in high antibody titers to M41 but low titers to D207.
- A prime-boost strategy (Mass live vaccine followed by bivalent killed vaccine) stimulated high antibody levels against both M41 and D207.
- Vaccinated hens showed good protection of egg production, correlating with antibody titers.
Conclusions:
- A prime-boost vaccination approach enhances protection against variant infectious bronchitis virus serotypes.
- Killed virus vaccines can be effectively used in laying hens when part of an optimized program.
- Development of live virus vaccines from variant IBV strains is warranted.
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