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Chromosome abnormalities in breast fibroadenomas.
G Calabrese1, C Di Virgilio, E Cianchetti
1Istituto di Biologia, Universitá di Chieti, Italy.
Genes, Chromosomes & Cancer
|May 1, 1991
Summary
Cytogenetic analysis of breast fibroadenomas revealed clonal chromosome changes in some tumors. An identical chromosomal aberration, t(11;12)(q21;q15), found in multiple fibroadenomas from one patient suggests a common origin.
Area of Science:
- Cytogenetics
- Oncology
- Human Genetics
Background:
- Breast fibroadenomas are common benign breast tumors.
- Understanding the genetic basis of fibroadenomas can provide insights into their development.
Purpose of the Study:
- To investigate the cytogenetic profile of breast fibroadenomas.
- To identify chromosomal abnormalities associated with fibroadenoma formation.
Main Methods:
- Cytogenetic analysis was performed on 25 breast fibroadenomas from 17 women.
- Structural chromosome changes were analyzed in tumor samples.
Main Results:
- Seven out of 25 tumors (from five patients) exhibited clonal structural chromosome changes.
- Breaks involving chromosome 12 were observed in three patients.
- An identical aberration, t(11;12)(q21;q15), was identified in three fibroadenomas from a single patient.
Conclusions:
- The presence of identical chromosomal aberrations in multiple fibroadenomas from the same patient strongly suggests a clonal origin.
- These findings contribute to understanding the molecular pathogenesis of breast fibroadenomas.