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Updated: Jul 3, 2026

Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody (mAb) by Neutralizing TNF Using an In Vitro Bioanalytical Method
Published on: September 16, 2017
[Adalimumab: the molecule and manufacturing procedure]
Z Martínez de Lagrán1, S Pérez-Barrio, J L Díaz-Pérez
1Servicio de Dermatología. Hospital de Cruces. Cruces (Vizcaya). España. ZURINE.MARTINEZDELAGRANALVAREZDEARCAYA@osakidetza.net
Abstract:
Adalimumab is a fully human monoclonal antibody targeted toward tumor necrosis factor alpha (TNF-alpha). TNF-alpha is proinflammatory cytokine involved in the pathogenesis of many inflammatory diseases, as the psoriasis. The production process of adalimumab is complex and it is based in the called phague display technology.
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