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Local regression: a new approach for measurement system comparison analysis
Andrea Geistanger1, Christoph Berding, Ewald Vorberg
1Department of Biostatistics, Roche Diagnostics GmbH, Penzberg, Germany. andrea.geistanger@roche.com
Abstract:
A new graphical approach for analysis of measurement system comparison studies is proposed. Unlike the established linear regression and Bland-Altman analysis, it does not depend on the assumption of a linear relationship. We review the established analysis approaches and propose a difference plot with non-parametric regression as an adequate tool to describe the relationship between two measurement systems. Along with pre-defined level-dependent acceptance limits, this approach may provide evidence for metrological equivalence between two measurement systems. Several data examples are given to illustrate this approach.
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