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Local regression: a new approach for measurement system comparison analysis.
Andrea Geistanger1, Christoph Berding, Ewald Vorberg
1Department of Biostatistics, Roche Diagnostics GmbH, Penzberg, Germany. andrea.geistanger@roche.com
A novel graphical method analyzes measurement system comparisons without assuming linear relationships. This approach uses difference plots and non-parametric regression to assess metrological equivalence, offering an alternative to traditional methods.
Area of Science:
- Metrology
- Statistical Analysis
- Measurement Science
Background:
- Traditional analysis of measurement system comparison studies often relies on linear regression or Bland-Altman methods.
- These established approaches may be limited by the assumption of a linear relationship between measurement systems.
- There is a need for flexible analytical tools that can accommodate non-linear relationships.
Purpose of the Study:
- To propose a new graphical approach for analyzing measurement system comparison studies.
- To offer an alternative to linear regression and Bland-Altman analysis that does not assume linearity.
- To provide a method for assessing metrological equivalence between two measurement systems.
Main Methods:
- Review of established analysis approaches for measurement system comparison.
- Proposal of a difference plot incorporating non-parametric regression.
- Inclusion of pre-defined level-dependent acceptance limits for equivalence assessment.
Main Results:
- The proposed graphical approach effectively describes the relationship between two measurement systems.
- The method demonstrates potential for providing evidence of metrological equivalence.
- Illustrative data examples confirm the applicability of the approach.
Conclusions:
- The novel graphical approach offers a robust alternative for measurement system comparison.
- This method is suitable for situations where linearity cannot be assumed.
- The difference plot with non-parametric regression aids in establishing metrological equivalence.
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