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Published on: May 1, 2015
Pseudolymphomatous angiokeratoma: report of three cases and an immunohistological study
R Okuyama1, T Masu, M Mizuashi
1Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan. rokuyama@mail.tains.tohoku.ac.jp
Background:
Pseudolymphomatous angiokeratoma (PA), originally termed 'acral pseudolymphomatous angiokeratoma of children', is a disorder characterized clinically by development of red nodules on the extremities and histologically by a subepidermal dense lymphocyte infiltrate.
Methods:
We report three cases of PA, with characteristically dense, nodular infiltrate composed predominantly of small lymphocytes, and thick-walled vessels.
Results:
Immunohistochemical investigation revealed a dense accumulation of CD20+ cells with CD3+ cells in one case. Infiltrate in the other two cases was mainly composed of CD3+ cells and a mixture of CD4+ and CD8+ cells, with a few cells expressing CD20.
Conclusion:
Our immunohistological results reveal a wide spectrum of cellular infiltrate compositions ranging from T-cell to B-cell predominance.