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Updated: Jul 3, 2026

Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats
Published on: January 21, 2020
Extensive skin necrosis of the arm in a patient with complex regional pain syndrome
M Nishikawa1, M Tanioka, E Araki
1Departments of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Abstract:
We report a 36-year-old woman with complex regional pain syndrome (CRPS) type 1 presenting with extensive skin necrosis of the left arm. The patient cooled her arm with ice packs to ease severe pain due to CRPS, in spite of repeated cautions against frostbite injury. The regions of skin necrosis corresponded with the sites where she had applied ice packs. We considered that the severe skin necrosis in our case was due to a self-induced frostbite injury.
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