Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endothelium-derived relaxing factor: basic review and clinical implications.

R A Johns1

  • 1Department of Anesthesiology, University of Virginia Health Sciences Center, Charlottesville 22908.

Journal of Cardiothoracic and Vascular Anesthesia
|February 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diagnosis and management of a ruptured 20-week anencephalic cornual ectopic pregnancy undergoing termination: implications of interstate travel due to restrictive abortion law.

International journal of obstetric anesthesia·2023
Same author

A case of pseudo-xanthoma elasticum presenting with ischaemic claudication.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2012
Same author

Post-synaptic density-93 mediates tyrosine-phosphorylation of the N-methyl-D-aspartate receptors.

Neuroscience·2008
Same author

A comparison of cyclizine and granisetron alone and in combination for the prevention of postoperative nausea and vomiting.

Anaesthesia·2006
Same author

Differential roles of neuronal and endothelial nitric oxide synthases during carrageenan-induced inflammatory hyperalgesia.

Neuroscience·2004
Same author

Evidence of neuronal excitatory amino acid carrier 1 expression in rat dorsal root ganglion neurons and their central terminals.

Neuroscience·2004
Same journal

Effect of the Duration of Cardiopulmonary Bypass on Oxygenation Predicted by Measuring Thoracic Fluid Content Using Electrical Cardiometry in Infants Undergoing Closure of Ventricular Septal Defect:A Prospective Observational Study.

Journal of cardiothoracic and vascular anesthesia·2026
Same journal

Renal Dysfunction Modifies the Prognostic Value of Lactate Clearance in Extracorporeal Cardiopulmonary Resuscitation: A Retrospective Interaction Analysis.

Journal of cardiothoracic and vascular anesthesia·2026
Same journal

Acute Severe Mitral Regurgitation Following Y-Incision Aortic Annular Enlargement Detected by Intraoperative Transesophageal Echocardiography.

Journal of cardiothoracic and vascular anesthesia·2026
Same journal

Association Between Preoperative Iron Deficiency and Postoperative Outcomes in Children Undergoing Cardiac Surgery.

Journal of cardiothoracic and vascular anesthesia·2026
Same journal

An Insight Into a Potential Antithrombin-Independent Mechanism of Inadequate Heparin Response in Neonates and Infants Undergoing Pediatric Cardiac Surgery: An Exploratory Study.

Journal of cardiothoracic and vascular anesthesia·2026
Same journal

The Efficacy and Safety of Weighted Blankets to Reduce Agitation After Cardiac Catheterization and Electrophysiology Procedures in Pediatric Patients With Congenital Heart Disease.

Journal of cardiothoracic and vascular anesthesia·2026
See all related articles

Endothelial-derived relaxing factor (EDRF) is a key vasodilator involved in vascular health. Its dysfunction contributes to diseases like hypertension and atherosclerosis, highlighting its therapeutic potential.

Area of Science:

  • Cardiovascular Physiology
  • Endothelial Function
  • Pharmacology

Background:

  • Endothelial-derived relaxing factor (EDRF) is a potent endogenous vasodilator synthesized from L-arginine.
  • EDRF activates soluble guanylate cyclase, increasing cyclic GMP and causing vascular smooth muscle relaxation.
  • Its role in human vascular physiology and pathophysiology is increasingly recognized.

Purpose of the Study:

  • To elucidate the chemical nature and synthetic pathways of EDRF.
  • To explore the implications of EDRF in various cell types beyond the cardiovascular system.
  • To investigate the interactions between anesthetics and EDRF in endothelial and non-endothelial cells.

Main Methods:

  • Characterization of EDRF's chemical structure and synthesis.

Related Experiment Videos

  • Investigation of EDRF's role in different physiological and pathophysiological states.
  • Analysis of anesthetic effects on EDRF production, release, and action.

    • Main Results:

    • EDRF is identified as nitric oxide (NO) or a related nitrogen oxide-containing compound.
    • EDRF activity is impaired in hypertension and atherosclerosis, implicated in vasospasm.
    • EDRF mediates flow-dependent vasodilation and its inhibition by hypoxia contributes to vasoconstriction.

    Conclusions:

    • Understanding EDRF's pathways can lead to novel treatments for vascular diseases.
    • EDRF's function extends beyond the cardiovascular system, impacting renal, respiratory, neuronal, and endocrine cells.
    • Further research is needed to clarify anesthetic-EDRF interactions and their clinical significance in various disease states.