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Related Concept Videos

The Thyroid Gland01:23

The Thyroid Gland

The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
Hyperthyroidism I: Introduction01:25

Hyperthyroidism I: Introduction

Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...
Hypothyroidism II: Pathophysiology01:23

Hypothyroidism II: Pathophysiology

Hypothyroidism is a disorder characterized by insufficient production of thyroid hormones, which regulate metabolism, energy balance, and multiple organ systems.TypesHypothyroidism is classified based on the level of dysfunction. Primary hypothyroidism results from intrinsic thyroid gland dysfunction, causing reduced hormone production despite normal or increased stimulation. Secondary hypothyroidism arises from inadequate thyroid-stimulating hormone (TSH) secretion by the pituitary. Tertiary...
Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...

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Related Experiment Video

Updated: Jul 3, 2026

Synchronous Triplanar Reconstruction Integrated with Color Doppler Mapping for Precise and Rapid Localization of Thyroid Lesions
05:41

Synchronous Triplanar Reconstruction Integrated with Color Doppler Mapping for Precise and Rapid Localization of Thyroid Lesions

Published on: February 9, 2024

Thyroid testing in Sloughis.

L Panakova1, H Koch, S Kolb

  • 1Veterinary Clinic Birkenfeld, Birkenfeld, Germany. lpanakova@yahoo.com

Journal of Veterinary Internal Medicine
|August 7, 2008
PubMed
Summary
This summary is machine-generated.

Sloughi dogs exhibit distinct thyroid hormone concentrations compared to other breeds. Veterinarians should consider these unique values when diagnosing hypothyroidism in Sloughis.

Related Experiment Videos

Last Updated: Jul 3, 2026

Synchronous Triplanar Reconstruction Integrated with Color Doppler Mapping for Precise and Rapid Localization of Thyroid Lesions
05:41

Synchronous Triplanar Reconstruction Integrated with Color Doppler Mapping for Precise and Rapid Localization of Thyroid Lesions

Published on: February 9, 2024

Area of Science:

  • Veterinary endocrinology
  • Canine health
  • Comparative physiology

Background:

  • Thyroid hormone levels vary significantly among dog breeds, notably differing in sight hounds like Greyhounds and Whippets from non-sight hounds.
  • Previous observations indicated lower thyroid hormone concentrations in Greyhounds compared to other breeds.

Purpose of the Study:

  • To investigate and characterize the thyroid hormone profiles of Sloughi dogs.
  • To compare thyroid hormone concentrations in Sloughis with those of a control group of non-sight hounds.
  • To assess the thyroid gland's response to stimulation in Sloughis.

Main Methods:

  • Analyzed thyroid profiles (total thyroxine, free thyroxine, free thyroxine after equilibrium dialysis, canine thyroid-stimulating hormone, thyroglobulin antibodies) in 51 healthy Sloughis.
  • Compared Sloughi results with a control group of normal dogs.
  • Performed thyroid-stimulating hormone (TSH) stimulation tests in 8 Sloughis.

Main Results:

  • Sloughis presented with significantly lower total thyroxine (tT4) and free thyroxine (fT4) concentrations compared to controls.
  • Elevated concentrations of fT4 after equilibrium dialysis (fT4 after ED) and canine thyroid-stimulating hormone (cTSH) were observed in Sloughis.
  • TSH stimulation resulted in a moderate increase in T4, with only 3 of 8 Sloughis reaching recommended post-stimulation levels. High prevalence of hemoconcentration and hypoglobulinemia noted.

Conclusions:

  • Sloughi dogs possess unique thyroid hormone concentrations, distinct from non-sight hounds.
  • Veterinarians must consider these breed-specific thyroid hormone levels when evaluating Sloughis for potential hypothyroidism.
  • The findings highlight the importance of breed-specific reference ranges in canine endocrinology.