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Cardiac incoordination induced by left bundle branch block: its relation with left ventricular systolic function in

Miguel Quintana1, Samir Saha, Satish Govind

  • 1Institution of Laboratory Medicine, Department of Cardiology, Hospital de Torrevieja, Spain. miguel.quintana@ki.se

Cardiovascular Ultrasound
|August 7, 2008
PubMed

Insights

Left bundle branch block (LBBB) severely disrupts myocardial coordination (MC), especially in patients with cardiomyopathy. This disruption significantly correlates with left ventricular (LV) systolic function, aiding in etiological evaluation.

Area of Science:

  • Cardiology
  • Cardiac Electrophysiology
  • Echocardiography

Background:

  • Left bundle branch block (LBBB) impacts cardiac electrical activation, but its effects on myocardial coordination (MC) and left ventricular (LV) systolic function remain unclear.
  • Understanding these effects is crucial for managing patients with LBBB, particularly those with underlying cardiomyopathies.

Purpose of the Study:

  • To assess the impact of LBBB on MC in patients with and without dilated (DCMP) or ischemic cardiomyopathy (ICMP).
  • To evaluate the relationship between altered MC and LV systolic function in the presence of LBBB.

Main Methods:

  • Tissue Doppler echocardiography (TDE) was used to analyze myocardial velocity profiles in 86 individuals (21 isolated LBBB, 26 DCMP + LBBB, 19 ICMP + LBBB, 20 Controls).
  • LV systolic function was assessed using standard 2D echocardiography and TDE.

Main Results:

  • Subjects with LBBB exhibited severe MC derangements compared to controls (P < 0.01).
  • These alterations were more pronounced in patients with DCMP and ICMP (P < 0.001 vs. Controls; P < 0.01 vs. isolated LBBB).
  • Significant correlations were found between MC variables and LV systolic function.

Conclusions:

  • LBBB induces significant MC derangements, particularly in cardiomyopathies, which correlate with LV systolic function.
  • Assessing MC may aid in evaluating the etiology of dilated cardiomyopathy.
Abstract

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