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Innate immune mechanism in allergic asthma
Carlos J Suarez1, Nathan J Parker, Patricia W Finn
1Division of Pulmonary and Critical Care, University of California, San Diego, 9500 Gilman Drive #0643, La Jolla, CA 92096-0643, USA.
Current Allergy and Asthma Reports
|August 7, 2008
Summary
This review explores how innate immunity contributes to allergic asthma. It highlights the roles of innate immune cells and molecules in allergic airway inflammation.
Area of Science:
- Immunology
- Pulmonology
- Allergy
Background:
- Allergic asthma is a chronic airway inflammatory disease.
- It involves eosinophilic inflammation, airway hyperresponsiveness, and mucus overproduction.
- Adaptive immunity is key, but innate immune responses also play a role.
Purpose of the Study:
- To review the evidence linking innate immunity to allergic asthma pathogenesis.
- To focus on the roles of specific innate immune cells and molecules.
Main Methods:
- Literature review of current evidence.
- Focus on innate immune cells: bronchial epithelial cells, alveolar macrophages, dendritic cells.
- Focus on innate immune molecules: Toll-like receptors, nucleotide-binding oligomerization domain-like receptors.
Main Results:
- Innate immune cells and molecules are implicated in allergic asthma.
- These components modify allergic immune responses.
- Evidence supports innate immunity's contribution to disease development.
Conclusions:
- Innate immunity is a significant factor in allergic asthma pathogenesis.
- Understanding these innate pathways offers potential therapeutic targets.
- Further research into innate immune mechanisms is warranted.
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