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Published on: August 15, 2019
[Linkage analysis of one family with autosomal dominant high myopia]
Jin-xia Chang1, Ding-ding Zhang, Yin Lin
1Department of Immunology, West China Medical Center, Sichuan University, Chengdu, Sichuan, 610041 People's Republic of China.
Objective:
To map the high myopia gene in a Chinese family with autosomal dominant high myopia.
Methods:
A family with autosomal dominant high myopia in three generations was collected. Eighteen short-tandem-repeat markers on previously reported loci linked to high myopia were chosen for genotyping and two-point linkage analysis was carried out.
Results:
The spherical equivalent of affected individuals ranges from -6.00D to -20.00D and the genetic pattern is autosomal dominant. The LOD score was less than -1 in all 18 microsatellite markers, indicating that there was no linkage between these markers and the high myopia related genes in this family.
Conclusion:
A novel myopia locus for high-grade myopia may exist in the kindred. Genome-wide scan will be needed to determine this novel locus.
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