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[Anemia as an independent predictor of poor long-term outcomes after percutaneous coronary intervention]
Xin-min Liu1, Jun-ping Kang, Qiang Lü
1Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
Insights
Anemia independently predicts worse long-term outcomes, including mortality, following percutaneous coronary intervention (PCI). This finding highlights the need for management strategies for anemic patients undergoing PCI.
Area of Science:
- Cardiology
- Hematology
- Interventional Cardiology
Context:
- Percutaneous coronary intervention (PCI) is a common procedure for treating coronary artery disease.
- Anemia is a prevalent condition in the general population and in patients undergoing cardiovascular procedures.
Purpose:
- To determine if anemia is an independent predictor of long-term outcomes after PCI.
- To evaluate the association between anemia and mortality and major adverse events post-PCI.
Summary:
- A registry study of 3809 PCI patients classified anemia using WHO criteria.
- Anemic patients (744) were older with more comorbidities, exhibiting higher mortality (4.7% vs 1.5%) and major adverse events (14.0% vs 10.8%) compared to non-anemic patients.
- After adjusting for comorbidities, anemia remained an independent predictor of increased mortality risk (RR 2.216, P=0.024) after PCI.
Impact:
- Anemia is identified as a significant independent risk factor for mortality post-PCI.
- The findings underscore the importance of developing management strategies for anemic patients undergoing PCI to improve long-term prognosis.
Objective:
To assess whether anemia is an independent predictor of poor long-term outcome after percutaneous coronary intervention (PCI).
Methods:
The second drug-eluting stent impact on revascularization registry (DESIRE-2) is a single-center registry of 6005 patients undergoing coronary revascularization from July 2003 to September 2005. We examined the clinical data and outcome of 3809 PCI patients based on hemoglobin (Hb) value before the interventional procedure. Patients were classified as anemia using the World Health Organization definition (< 120 g/L in women and < 130 g/L in men). 744 of the 3809 patients were anemic. We compared the clinical features and prognosis of the patients with or without anemia.
Results:
Anemic patients were older and had a higher percentage of comorbidities as compared with the nonanemic ones. When compared with nonanemic patients, anemic patients had higher mortality (4.7% vs 1.5%, P < 0.001) and higher major adverse event end points, including nonfatal myocardial infarction, stroke and revascularization (14.0% vs 10.8%, P = 0.014). After adjustment for comorbidities, anemia was associated with a higher risk of mortality after percutaneous coronary intervention (RR 2.216, 95% CI 1.019-4.428; P = 0.024).
Conclusions:
Anemia is an independent predictor of mortality after PCI. Since PCI is a common procedure and anemia is a frequent condition in the general population, strategies for the management of anemic PCI patients should be developed.
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