Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jul 3, 2026

A Passive Ankle Dorsiflexion Testing System for an In Vivo Model of Overuse-induced Tendinopathy

A Passive Ankle Dorsiflexion Testing System for an In Vivo Model of Overuse-induced Tendinopathy

Published on: March 1, 2024

Subrupture tendon fatigue damage.

David T Fung¹, Vincent M Wang¹, Damien M Laudier¹

¹Leni and Peter W. May Department of Orthopaedics, Mount Sinai School of Medicine, 5 East 98th Street, 9th Floor, New York, New York 10029.

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society

|August 8, 2008

Summary

This summary is machine-generated.

Related Concept Videos

Fatigue

Fatigue

Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Panx1 and P2X7R are associated with impaired skeletal health and delayed bone development in early onset of type 1 diabetes.

Frontiers in endocrinology·2026

Same author

Anatomic Total Shoulder Arthroplasty: Long-Term Clinical, Radiographic, and Patient-Reported Outcomes.

The Journal of the American Academy of Orthopaedic Surgeons·2026

Same author

Transcriptional Adaptations to Muscle Loading in a Murine Model of Achilles Tendinopathy.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society·2026

Same author

To fall or not to fall: the question of hip fracture prevention.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2025

Same author

Fostering Interest in Musculoskeletal Research and Science, Technology, Engineering, Mathematics (STEM) Careers: Impact of the ORS Open Door Program, 2020-2025.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society·2025

Same author

A multi-mineral intervention to improve disease-related and mechanistic biomarkers in ulcerative colitis patients: Results from a randomized trial.

PloS one·2025

Tendon fatigue damage progresses with increasing strain, leading to microstructural changes like fiber kinking and rupture. Tendon deformation accurately tracks this damage accumulation during fatigue.

Area of Science:

Biomechanical Engineering
Materials Science
Orthopedic Research

Background:

Tendon fatigue, characterized by accumulating damage and degradation, lacks clear mechanical and microstructural understanding.
Investigating the underlying mechanisms of tendon fatigue is crucial for understanding overuse injuries and developing effective interventions.

Purpose of the Study:

To elucidate the mechanical and microstructural basis of tendon fatigue.
To identify reliable mechanical parameters for assessing tendon damage progression.

Main Methods:

Rat flexor digitorum longus tendons were subjected to cyclic loading to induce low, moderate, and high fatigue damage levels.
Mechanical properties (stiffness, hysteresis, clamp-to-clamp strain) were measured before and after fatigue loading.

More Related Videos

Ex vivo Mechanical Loading of Tendon

Ex vivo Mechanical Loading of Tendon

Published on: May 28, 2007

Related Experiment Videos

Last Updated: Jul 3, 2026

A Passive Ankle Dorsiflexion Testing System for an In Vivo Model of Overuse-induced Tendinopathy

A Passive Ankle Dorsiflexion Testing System for an In Vivo Model of Overuse-induced Tendinopathy

Published on: March 1, 2024

Ex vivo Mechanical Loading of Tendon

Ex vivo Mechanical Loading of Tendon

Published on: May 28, 2007

Microstructural analysis, including histomorphometry, was performed to correlate mechanical changes with structural damage.

Main Results:

Tendon clamp-to-clamp strain increased significantly and progressively with fatigue damage level.
Stiffness and hysteresis changes were significant only at high fatigue levels.
Microstructural analysis revealed fiber kinking at low fatigue, progressing to fiber dissociation and rupture at higher levels, with increased damage area fraction.

Conclusions:

Tendon deformation is a sensitive indicator of fatigue damage accumulation.
Sequential microstructural events, from fiber kinking to rupture, underlie the tendon fatigue process.
Mechanical parameters can be used to assess the progression of tendon fatigue damage.