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Related Experiment Video

Updated: Jul 3, 2026

A Choroid Plexus Epithelial Cell-based Model of the Human Blood-Cerebrospinal Fluid Barrier to Study Bacterial Infection from the Basolateral Side

A Choroid Plexus Epithelial Cell-based Model of the Human Blood-Cerebrospinal Fluid Barrier to Study Bacterial Infection from the Basolateral Side

Published on: May 6, 2016

Choroid plexus carcinoma.

Purva Gopal¹, John R Parker, Robert Debski

¹Department of Pathology and Laboratory Medicine, University of Louisville, Louisville, KY, USA.

Archives of Pathology & Laboratory Medicine

|August 8, 2008

Summary

This summary is machine-generated.

Choroid plexus carcinoma is a rare central nervous system tumor primarily affecting children. Early and complete surgical resection offers the best prognosis for this aggressive neoplasm.

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Area of Science:

Neuro-oncology
Pediatric Pathology
Central Nervous System Neoplasms

Background:

Choroid plexus carcinoma is a rare central nervous system neoplasm.
It predominantly affects the pediatric population.
This tumor carries a poor prognosis, particularly with incomplete resection.

Purpose of the Study:

To highlight the key histopathologic features of choroid plexus carcinoma.
To emphasize its importance in the differential diagnosis of papillary intraventricular tumors.
To discuss current treatment strategies and controversies.

Main Methods:

Histopathologic examination of tumor samples.
Review of clinical presentation and treatment outcomes.
Differential diagnosis considerations for intraventricular tumors.

Main Results:

Key features include blurred papillary architecture, neoplastic choroid plexus cells with pleomorphic nuclei, high nuclear-to-cytoplasmic ratio, increased mitoses, necrosis, and brain invasion.
Gross total surgical resection is the primary treatment goal.
Adjuvant chemotherapy use remains controversial but is considered in select cases.

Conclusions:

Accurate histopathologic diagnosis is crucial for appropriate management.
Choroid plexus carcinoma requires consideration in pediatric papillary intraventricular tumors.
Multidisciplinary approaches are essential for optimizing patient outcomes.