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Apoptotic sensitivity of murine IAP-deficient cells

Julie M Rumble1, Mathieu J M Bertrand, Rebecca A Csomos

  • 1Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.

The Biochemical Journal
|August 8, 2008
PubMed

Although numerous studies have implicated the IAPs (inhibitor of apoptosis proteins) in the control of apoptotic cell death, analyses of murine Iap-targeted cells have not revealed significant differences in their susceptibility to apoptosis. In the present study, we show that, under defined conditions, murine cells lacking XIAP (X-linked inhibitor of apoptosis) and c-IAP (cellular IAP) 2, but not c-IAP1, exhibit heightened apoptotic sensitivity to both intrinsic and extrinsic apoptotic stimuli.

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