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Prognostic implication of frailty and depressive symptoms in an outpatient population with heart failure

Josep Lupón1, Beatriz González, Sebastián Santaeugenia

  • 1Unitat d'Insuficiència Cardíaca, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain. jlupon.germanstrias@gencat.cat

Revista Espanola De Cardiologia
|August 8, 2008
PubMed

Insights

Frailty significantly increases 1-year mortality risk in heart failure patients. While frailty also predicts heart failure hospitalizations, only frailty independently predicts mortality.

Area of Science:

  • Cardiology
  • Geriatrics
  • Public Health

Background:

  • Heart failure (HF) is frequently associated with high levels of frailty and patient dependence.
  • Understanding factors influencing outcomes in HF is crucial for improving patient care.

Purpose of the Study:

  • To investigate the impact of frailty and depressive symptoms on 1-year mortality and HF hospitalization rates.
  • To identify independent predictors of adverse outcomes in heart failure patients.

Main Methods:

  • A cohort of 622 heart failure patients underwent geriatric evaluations to assess frailty and depressive symptoms.
  • Patients were followed for 1 year to record mortality and hospitalization events.
  • Demographic and clinical data, including ejection fraction and New York Heart Association class, were collected.

Main Results:

  • During the 1-year follow-up, 9.5% of patients died and 16.2% were hospitalized for heart failure.
  • Frailty was present in 39.9% of patients, and depressive symptoms in 25.2%.
  • Frailty and depressive symptoms were significantly associated with 1-year mortality. Frailty was also significantly associated with heart failure hospitalization, but not depressive symptoms.

Conclusions:

  • Frailty and depressive symptoms are linked to increased 1-year mortality in heart failure patients.
  • Frailty independently predicts mortality, highlighting its prognostic value.
  • Frailty is associated with heart failure hospitalizations, but does not independently predict them.
Abstract

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