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Stacking the deck for drug discovery in diabetic nephropathy: in search of an animal model

Matthew D Breyer

    Journal of the American Society of Nephrology : JASN
    |August 8, 2008
    PubMed
    Abstract

    No abstract available in PubMed .

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    Diabetic Nephropathy01:28

    Diabetic Nephropathy

    Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...