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Updated: Jul 3, 2026

Real Time In Vivo Tracking of Thymocytes in the Anterior Chamber of the Eye by Laser Scanning Microscopy
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Published on: October 2, 2018

Thymic emigration: when and how T cells leave home

Michael A Weinreich1, Kristin A Hogquist

  • 1Center for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.

Journal of Immunology (Baltimore, Md. : 1950)
|August 8, 2008
PubMed

The thymus supports the differentiation of multiple distinct T cell subsets that play unique roles in the immune system. CD4 and CD8 alpha/beta T cells, gamma/delta T cells, NKT cells, regulatory T cells, and intraepithelial lymphocytes all develop in the thymus and must leave it to provide their functions elsewhere in the body. This article will review recent research indicating differences in the time and migration patterns of T cell subsets found in the thymus. Additionally, we review current understanding of the molecules involved in thymocyte emigration, including the sphingolipid receptor S1P(1) and its regulation by the Krüppel-like transcription factor KLF2.

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