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Early hepatitis during intravenous amiodarone administration
S Morelli1, V Guido, P De Marzio
1Istituto di Clinica Medica I, University La Sapienza of Rome, Andrea Cesalpino Foundation, Italy.
Cardiology
|January 1, 1991
Summary
Parenteral amiodarone may cause acute hepatitis. Liver function normalized despite continued amiodarone infusion in two patients, suggesting potential drug tolerance.
Area of Science:
- Hepatology
- Cardiology
- Clinical Pharmacology
Background:
- Parenteral amiodarone is used for cardiac arrhythmias.
- Hepatotoxicity is a known adverse effect of amiodarone.
Observation:
- Two patients developed acute hepatitis following parenteral amiodarone administration.
- No alternative causes for the observed liver damage were identified.
Findings:
- Liver function tests improved in both patients despite the continuation of amiodarone infusion.
- This suggests a potential for adaptation or tolerance to the hepatotoxic effects of amiodarone.
Implications:
- Clinicians should monitor liver function in patients receiving parenteral amiodarone.
- Further research is warranted to understand the mechanism of amiodarone-induced hepatitis and potential for tolerance.