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Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
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Conserved residues modulate copper release in human copper chaperone Atox1

Faiza Hussain1, John S Olson, Pernilla Wittung-Stafshede

  • 1Department of Biochemistry and Cell Biology, Keck Center for Structural Computational Biology, Houston, TX 77251, USA.

Proceedings of the National Academy of Sciences of the United States of America
|August 8, 2008
PubMed
Summary

The human copper chaperone Atox1 facilitates copper delivery to Wilson and Menkes disease proteins. Mutants showed faster copper release, suggesting chaperones enhance copper accessibility for disease protein targets.

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