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Updated: Jul 3, 2026

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
Triazole-linked host compounds for chiral-discrimination toward amino acid ester guests
Hirofumi Sato1, Motohiro Shizuma
1Department of Biochemistry, Osaka Municipal Technical Research Institute, Japan. hsato@omtri.city.osaka.jp
Abstract:
The chiral-discriminating abilities of new triazole-linked host compounds (6, 7) toward amino acid esters were evaluated by the FABMS/EL-guest method. Two types of host appending saccharide derivatives were synthesized by the copper-catalyzed Huisgen-1,3-dipolar cycloaddition (CuAAC). Host compounds binding constants and chiral-discriminating abilities toward the enantiomeric alanine esters were evaluated by UV method in chloroform. The structural requirements of triazole-linked hosts were determined by their chiral-discriminating behaviors.
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