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Related Experiment Video

Updated: Jul 3, 2026

Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis

Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis

Published on: May 12, 2019

Measuring tools for gastrointestinal toxicity.

Ross N Butler¹

¹Centre for Paediatric and Adolescent Gastroenterology, Women's and Children's Hospital, Children Youth and Women's Health Service, Adelaide, South Australia, Australia. ross.butler@adelaide.edu.au

Current Opinion in Supportive and Palliative Care

|August 8, 2008

Summary

Noninvasive functional biomarkers, like the C sucrose breath test, now enable monitoring of gastrointestinal damage and repair from chemotherapy. This aids in evaluating new treatments for mucositis in cancer patients.

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Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis

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Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation

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Ex Vivo Intestinal Sacs to Assess Mucosal Permeability in Models of Gastrointestinal Disease

Ex Vivo Intestinal Sacs to Assess Mucosal Permeability in Models of Gastrointestinal Disease

Published on: February 9, 2016

Area of Science:

Oncology
Gastroenterology
Biomarker Development

Background:

Limited noninvasive biomarkers previously existed for assessing chemotherapy-induced gastrointestinal toxicity.
Evaluating the extent and severity of gastrointestinal damage in animal models and cancer patients was challenging.

Purpose of the Study:

To review the advancements in noninvasive functional biomarkers for gastrointestinal toxicity.
To highlight the utility of these biomarkers in monitoring damage and repair during cancer therapy.

Main Methods:

Review of recent findings on noninvasive functional biomarkers.
Application of the C sucrose breath test in animal models of chemotherapeutic damage.
Analysis of studies involving mucositis in childhood cancer patients.

Main Results:

Noninvasive functional biomarkers allow longitudinal monitoring of gastrointestinal damage and repair.
Objective evidence for the efficacy of antimucositis agents can be collected in animal models.
The C sucrose breath test demonstrates rapid monitoring of bioactive molecule efficacy in damage and repair cycles.

Conclusions:

The C sucrose breath test is a valuable tool for monitoring chemotherapy-induced gastrointestinal damage and repair.
This biomarker shows promise for evaluating new treatments in clinical trials and routine management of mucositis.
Future applications may include predicting damage in other gastrointestinal regions, such as the oral mucosa.