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Related Concept Videos

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Chronic Obstructive Pulmonary Disease01:24

Chronic Obstructive Pulmonary Disease

COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations01:19

Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations

Chronic Obstructive Pulmonary Disease, or COPD, is a long-term condition marked by persistent and only partially reversible airflow limitation. It involves two overlapping conditions—chronic bronchitis and emphysema—which often co-appear but differ in dominant symptoms and underlying mechanisms.Chronic Bronchitis FeaturesChronic bronchitis presents with a persistent productive cough and thick, sometimes purulent mucus due to airway inflammation, enlarged mucus glands, and goblet cell...
Chronic Obstructive Pulmonary Disease I: Introduction01:23

Chronic Obstructive Pulmonary Disease I: Introduction

Chronic obstructive pulmonary disease is a common, preventable, and treatable respiratory disorder characterized by persistent symptoms and progressive airflow limitation. This limitation results from a combination of small-airway disease (obstructive bronchiolitis) and parenchymal destruction (emphysema), both driven by chronic inflammation from exposure to harmful particles or gases.The disease includes two main pathological entities: emphysema, marked by destruction of alveolar walls and...
Chronic Obstructive Pulmonary Disease-I: Introduction01:20

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:

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Related Experiment Video

Updated: Jul 3, 2026

Methods for Detecting Cough and Airway Inflammation in Mice
04:33

Methods for Detecting Cough and Airway Inflammation in Mice

Published on: August 2, 2024

Chronic cough.

Bee Wee1

  • 1Sir Michael Sobell House, Oxford Radcliffe Hospitals NHS Trust and Nuffield Department of Medicine, Medical Sciences Division and Harris Manchester College, Oxford University, Oxford, UK. bee.wee@hmc.ox.ac.uk

Current Opinion in Supportive and Palliative Care
|August 8, 2008
PubMed
Summary
This summary is machine-generated.

Chronic cough is a distressing symptom often overlooked in serious illness. While assessment tools have improved, effective new treatments for chronic cough remain limited, highlighting a need for further research.

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Area of Science:

  • Palliative Care Medicine
  • Respiratory Medicine
  • Symptom Management

Background:

  • Chronic cough is a prevalent and distressing symptom, particularly in patients with life-threatening illnesses.
  • It often receives less attention than other symptoms like pain or breathlessness.
  • Limited research exists specifically within supportive and palliative care contexts.

Purpose of the Study:

  • To review recent advancements in cough research, covering mechanisms, assessment, and management.
  • To highlight the current state of knowledge and identify gaps in supportive and palliative care.
  • To emphasize the need for systematic approaches to cough assessment and intervention.

Main Methods:

  • Literature review of recent cough research.
  • Analysis of advancements in objective cough measurement devices.
  • Evaluation of subjective assessment tools, including quality of life questionnaires.

Main Results:

  • Objective cough measurement has improved with new devices.
  • Practical, user-friendly subjective assessment tools are now available for clinical practice.
  • Despite advancements in assessment, there have been no significant therapeutic breakthroughs in over a decade.

Conclusions:

  • Clinicians should systematically assess and manage chronic cough using available tools.
  • Current mainstay oral therapies include dextromethorphan, codeine, and morphine.
  • Significant research potential exists, from basic science to clinical trials for novel therapies.