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Updated: Jul 3, 2026
07:24
Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube (SWCNT)-delivered MALAT1 Antisense Oligos
Published on: December 13, 2018
New drugs in multiple myeloma
1Institute for Myeloma and Bone Cancer Research, USA bOncotherapeutics, Los Angeles, California 90069, USA. jberenson@imbcr.org
Current Opinion in Supportive and Palliative Care
|August 8, 2008
Summary
New targeted therapies, including bortezomib and lenalidomide, have significantly improved multiple myeloma treatment outcomes. These advancements offer better efficacy and safety for patients, including those with relapsed or refractory disease.
Area of Science:
- Hematology
- Oncology
- Pharmacology
Background:
- Multiple myeloma is an aggressive hematological neoplasia.
- Understanding its pathogenesis has driven the development of targeted therapies.
Purpose of the Study:
- To review clinical trials supporting new multiple myeloma agents.
- To examine emerging drugs in early-phase studies.
Main Methods:
- Review of clinical trials and preclinical data.
- Focus on targeted therapies and novel drug candidates.
Main Results:
- Bortezomib and lenalidomide have emerged as key therapies.
- Reintroduction of thalidomide and arsenic trioxide.
- New agents show increased response rates and improved safety profiles.
- Emerging therapies include HDAC, hsp90, mTOR, and Akt inhibitors.
Conclusions:
- The new arsenal of multiple myeloma drugs is effective in both relapsed/refractory and frontline settings.
- These therapies provide valuable options for patients with debilitating multiple myeloma.
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