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Updated: Jul 3, 2026

Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model
Published on: October 2, 2015
Commensal bacteria and "oncologic surveillance": suggestions from an experimental model
Cristiano Pagnini1, Vito D Corleto, Sharon B Hoang
1II School of Medicine, University of Rome La Sapienza, Rome, Italy. cristiano.pagnini@uniroma1.it
Abstract:
The relationship between resident intestinal flora and colon cancer development are not yet clear. Apoptosis induction could represent a mechanism by which commensal and/or probiotic bacteria could prevent proliferation of dysplastic cells. In the present study, the in vivo and in vitro proapoptotic effect of resident bacteria was evaluated in mouse colon mucosa. Preliminary results suggest that colonic apoptosis induction, by commensal bacteria, could possibly represent a physiologic "oncologic surveillance" mechanism for colonic proliferative disease prevention.
