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Next-generation Sequencing03:00

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.
Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
Genome Annotation and Assembly03:36

Genome Annotation and Assembly

The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
Synthetic Biology02:55

Synthetic Biology

Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...

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Related Experiment Video

Updated: Jul 3, 2026

Leveraging CyVerse Resources for De Novo Comparative Transcriptomics of Underserved (Non-model) Organisms
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Leveraging CyVerse Resources for De Novo Comparative Transcriptomics of Underserved (Non-model) Organisms

Published on: May 9, 2017

The next meta-challenge for Bioinformatics.

Willy Valdivia-Granda1

  • 1Orion Integrated Biosciences Inc., New York, United States of America. Willy.Valdivia@orionbiosciences.com

Bioinformation
|August 8, 2008
PubMed
Summary
This summary is machine-generated.

Metagenomics enables direct DNA sequencing from uncultivable organisms, revealing novel life and functions. This field presents computational challenges but offers vast biomedical, agricultural, and industrial applications.

Keywords:
enterprise databasegenomic barcodinghigh performance computingmetagenomics

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Leveraging CyVerse Resources for De Novo Comparative Transcriptomics of Underserved (Non-model) Organisms
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Area of Science:

  • Microbiology
  • Genomics
  • Bioinformatics

Background:

  • Direct sequencing of uncultivable organisms in complex samples offers potential for discovering new life forms and metabolic processes.
  • Metagenomics, a rapidly advancing field, generates vast amounts of molecular data.
  • Conventional computational analysis and visualization algorithms struggle to keep pace with the scale of metagenomic data.

Purpose of the Study:

  • To highlight emerging computational challenges in metagenomics.
  • To identify opportunities for developing applications that translate metagenomic data.
  • To bridge the gap between metagenomic data and practical applications.

Main Methods:

  • Direct sequencing of environmental DNA.
  • Computational analysis of large-scale molecular datasets.
  • Algorithm development for metagenomic data interpretation.

Main Results:

  • Identification of novel organisms and metabolic pathways.
  • Recognition of computational bottlenecks in data analysis.
  • Potential for new applications across various sectors.

Conclusions:

  • Metagenomics is a transformative field with significant potential for discovery.
  • Addressing computational challenges is crucial for realizing the full potential of metagenomics.
  • Metagenomic insights can drive innovation in biomedical, agricultural, environmental, and industrial fields.