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A ciprofloxacin extended release tablet based on swellable drug polyelectrolyte matrices
José M Bermúdez1, Alvaro F Jimenez-Kairuz, Maria E Olivera
1Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria, X5000HUA, Córdoba, Argentina.
AAPS Pharmscitech
|August 8, 2008
Summary
This study developed extended-release ciprofloxacin tablets using swellable drug polyelectrolyte matrices (SDPM). Matrix composition, specifically sodium content, effectively controlled drug release rates for flexible extended-release formulations.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Extended-release drug delivery systems are crucial for improving therapeutic efficacy and patient compliance.
- Ciprofloxacin is a widely used antibiotic requiring effective delivery strategies to maintain therapeutic levels.
Purpose of the Study:
- To develop extended-release (ER) tablets of 500 mg ciprofloxacin using swellable drug polyelectrolyte matrices (SDPM).
- To investigate the influence of sodium content in carbomer-ciprofloxacin complexes on drug release kinetics.
- To create a flexible drug delivery system for controlled ciprofloxacin release.
Main Methods:
- Preparation of carbomer-ciprofloxacin-sodium complexes with varying sodium proportions.
- Characterization of complexes using FT-IR, powder X-ray diffraction, and thermal analysis.
- Formulation of SDPM tablets and evaluation of fluid uptake and ciprofloxacin release in simulated gastric fluid.
Main Results:
- Ciprofloxacin was ionically bonded to carbomer functional groups within the complexes.
- Sodium content directly modulated fluid uptake and ciprofloxacin release rates, ranging from 1.4 to 25 mg/min.
- The developed system allowed for modulation of release to achieve 90% drug release within 120 minutes.
Conclusions:
- Extended-release ciprofloxacin tablets can be successfully developed using SDPM technology.
- The sodium content in the polyelectrolyte matrix is a key factor in controlling drug release kinetics.
- This flexible system enables tailored drug release profiles for optimized therapeutic outcomes.
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