Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Oral oxycodone self-administration leads to features of opioid misuse in male and female mice.

Addiction biology·2022
Same author

Advances in 3D-Printed Surface-Modified Ca-Si Bioceramic Structures and Their Potential for Bone Tumor Therapy.

Materials (Basel, Switzerland)·2021
Same author

Effect of Precursor Deficiency Induced Ca/P Ratio on Antibacterial and Osteoblast Adhesion Properties of Ag-Incorporated Hydroxyapatite: Reducing Ag Toxicity.

Materials (Basel, Switzerland)·2021
Same author

CAR-T cells: Early successes in blood cancer and challenges in solid tumors.

Acta pharmaceutica Sinica. B·2021
Same author

Effect of Paclitaxel/etoposide co-loaded polymeric nanoparticles on tumor size and survival rate in a rat model of glioblastoma.

International journal of pharmaceutics·2021
Same author

Nanoscale pathogens treated with nanomaterial-like peptides: a platform technology appropriate for future pandemics.

Nanomedicine (London, England)·2021

Related Experiment Video

Updated: Jul 3, 2026

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

Nano rough micron patterned titanium for directing osteoblast morphology and adhesion.

Sabrina Puckett1, Rajesh Pareta, Thomas J Webster

  • 1Division of Engineering, Brown University, Providence, RI 02917, USA.

International Journal of Nanomedicine
|August 9, 2008
PubMed
Summary

Aligned nanophase titanium surfaces enhance osteoblast (bone-forming cell) adhesion and morphology. Optimizing nanostructure dimensions is key for improving orthopedic implant success.

More Related Videos

Photopatterning Proteins and Cells in Aqueous Environment Using TiO2 Photocatalysis
10:26

Photopatterning Proteins and Cells in Aqueous Environment Using TiO2 Photocatalysis

Published on: October 26, 2015

Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications
09:56

Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications

Published on: December 8, 2015

Related Experiment Videos

Last Updated: Jul 3, 2026

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

Photopatterning Proteins and Cells in Aqueous Environment Using TiO2 Photocatalysis
10:26

Photopatterning Proteins and Cells in Aqueous Environment Using TiO2 Photocatalysis

Published on: October 26, 2015

Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications
09:56

Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications

Published on: December 8, 2015

Area of Science:

  • Biomaterials Science
  • Cell Biology
  • Surface Engineering

Background:

  • Nanophase metals show enhanced osteoblast function compared to conventional metals.
  • Bone's natural nanostructure features aligned nanoscale components.
  • Previous research has not explored the impact of organized nanosurface features on osteoblast interactions.

Purpose of the Study:

  • To investigate if surface feature orientation influences osteoblast adhesion and morphology.
  • To evaluate osteoblast function on patterned titanium substrates with alternating micron and nano rough regions.
  • To determine the effect of patterned region size on osteoblast behavior and alignment.

Main Methods:

  • Utilized novel electron beam evaporation techniques to create patterned titanium substrates.
  • Investigated osteoblast adhesion and morphology on surfaces with alternating micron and nano rough regions.
  • Varied the width of nano rough regions (80 microm to 22 microm) to assess pattern dimension effects.

Main Results:

  • Observed controlled osteoblast alignment on patterned titanium surfaces.
  • Found increased osteoblast adhesion on nano rough regions.
  • Decreasing nano rough region width reduced osteoblast adhesion and altered cell morphology, indicating an optimal pattern dimension.

Conclusions:

  • Aligned nanophase titanium features improve early osteoblast functions (adhesion, morphology).
  • Surface feature orientation and dimension significantly impact osteoblast behavior.
  • These findings suggest potential for enhanced orthopedic implant efficacy through optimized nanostructured surfaces.