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[Multiple center collaborative research on high risk population screening measure]

Zhen Hong1

  • 1Institute of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, China. profzhong@sina.com.cn

Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi
|August 9, 2008
PubMed

Insights

The cerebrovascular hemodynamic synthesized score (CVHS) effectively screens individuals at high risk for stroke. This score is a strong, independent predictor of stroke incidence, aiding in preventative measures.

Area of Science:

  • Neurology
  • Cardiovascular Science
  • Biomedical Engineering

Context:

  • Stroke remains a leading cause of disability and death worldwide.
  • Accurate identification of high-risk populations is crucial for effective stroke prevention strategies.
  • Cerebrovascular hemodynamics play a significant role in stroke pathogenesis.

Purpose:

  • To validate the efficacy of the cerebrovascular hemodynamic synthesized score (CVHS) for screening high-risk stroke populations.
  • To determine the relative risk (RR) associated with CVHS in predicting stroke.
  • To evaluate the performance of CVHS as a screening tool.

Summary:

  • A cohort of 23,741 participants aged 40+ free of stroke were assessed using the Cerebral Blood Vessel Analyzer (CBA) CV 300 to measure various hemodynamic indices.
  • The cerebrovascular hemodynamic synthesized score (CVHS) was calculated, and its predictive value for stroke was analyzed over 48,481 person-years.
  • Low CVHS (< 75) was associated with a 9.3-fold increased risk of stroke, demonstrating a significant dose-response relationship and identifying CVHS as the strongest independent predictor.

Impact:

  • CVHS demonstrated satisfactory screening efficacy with 80.77% sensitivity and 67.55% specificity.
  • The area under the ROC curve (AUC) of 0.806 indicates good discriminatory power.
  • CVHS can serve as a valuable tool for identifying individuals at high risk of stroke, facilitating targeted interventions and stroke prevention efforts.
Abstract

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