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Total synthesis of the originally proposed and revised structures of scleritodermin A

Sheng Liu1, Yong-Mei Cui, Fa-Jun Nan

  • 1Chinese National Center for Drug Screening, State Key Laboratory of Drug Research Shanghai Institute of Materia Medica, Chinese Academy of Sciences 189 Guoshoujing Road, Zhangjiang Hi-Tech Park, Shanghai 201203,China.

Organic Letters
|August 9, 2008
PubMed

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Protein and Protein Structure

Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme can...