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Published on: January 26, 2016
Cyclopeptides with anti-inflammatory activity from seeds of Annona montana
Pei-Hsuan Chuang1, Pei-Wen Hsieh, Yu-Liang Yang
1Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China.
Journal of Natural Products
|August 9, 2008
Abstract:
Four new cyclopeptides, cyclomontanins A-D (1- 4), annomuricatin C (5), and (+)-corytuberine were isolated from a methanol extract of Annona montana seeds. Their structures were elucidated by 2D NMR analysis, ESIMS/MS fragment evidence, and chemical means. The structure of 1 was confirmed by synthesis. Compounds 1, 3, and 4 exhibited anti-inflammatory activity in vitro using the J774.1 macrophage model.
