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Patch testing with amalgam at various concentrations.

J von Mayenburg1, J Rakoski, C Szliska

  • 1Department of Dermatology, Technical University of Munich, FRG.

Contact Dermatitis
|April 1, 1991
PubMed
Summary
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This study investigated mercury and amalgam allergies in 27 patients. Ten out of thirteen women with amalgam allergies reacted to a 5% concentration, suggesting this as a key testing level.

Area of Science:

  • Dermatology
  • Allergology
  • Toxicology

Background:

  • Mercury and its compounds, including dental amalgam, are known contact allergens.
  • Previous patch testing identified patients with positive reactions to mercury screening allergens.
  • The optimal concentration for patch testing amalgam allergies requires further definition.

Purpose of the Study:

  • To evaluate patient reactions to various mercury patch test preparations.
  • To determine the lowest effective concentration of amalgam for patch testing.
  • To explore the clinical significance and demographic patterns of amalgam reactivity.

Main Methods:

  • Twenty-seven patients with positive D3 reactions to mercury screening allergens underwent patch testing.
  • Testing included 13 mercury preparations (6 inorganic, 7 organic) and 20% amalgam in petrolatum.

Related Experiment Videos

  • Patients reacting to amalgam were further tested with serially reduced concentrations.
  • Main Results:

    • Thirteen patients (all female) reacted positively to 20% amalgam.
    • Of these, 10 patients reacted to 5% amalgam concentration.
    • Reactions were observed down to 1% concentration in two patients.

    Conclusions:

    • A 5% amalgam concentration appears significant for patch testing in sensitive individuals.
    • The study highlights a female predominance in amalgam reactivity.
    • Further research is recommended on the clinical relevance and gender distribution of amalgam allergy.