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Related Experiment Video

Updated: Jul 3, 2026

Induction of Experimental Autoimmune Hypophysitis in SJL Mice
10:38

Induction of Experimental Autoimmune Hypophysitis in SJL Mice

Published on: December 17, 2010

sirt1-null mice develop an autoimmune-like condition.

Jedon Sequeira1, Gino Boily, Stephanie Bazinet

  • 1Center for Cancer Therapeutics, Ottawa Health Research Institute, Box 926, 3rd Floor, 501 Smyth Road, Ottawa, Ontario, Canada K1H 8L6.

Experimental Cell Research
|August 9, 2008
PubMed
Summary
This summary is machine-generated.

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Mice lacking the SIRT1 gene develop autoimmune diseases, indicated by antibodies and immune deposits. This suggests SIRT1 protein is crucial for maintaining immune function and preventing autoimmune conditions.

Area of Science:

  • Immunology
  • Genetics
  • Molecular Biology

Background:

  • The sirt1 gene encodes a protein deacetylase with numerous substrates.
  • SIRT1's precise biological functions are not fully understood.

Purpose of the Study:

  • To investigate biological processes dependent on SIRT1 using sirt1-null mice.
  • To elucidate the role of SIRT1 in immune function and autoimmune disease.

Main Methods:

  • Generation and analysis of sirt1-null mice on outbred genetic backgrounds.
  • Examination of sera for autoantibodies and immune complex deposition in organs.
  • Clinical observation of sirt1-null mice for age-related diseases.

Main Results:

  • Sera from adult sirt1-null mice showed antibodies against nuclear antigens.

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Last Updated: Jul 3, 2026

Induction of Experimental Autoimmune Hypophysitis in SJL Mice
10:38

Induction of Experimental Autoimmune Hypophysitis in SJL Mice

Published on: December 17, 2010

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

Simultaneous Isolation of Principal Central Nervous System-Resident Cell Types from Adult Autoimmune Encephalomyelitis Mice
08:49

Simultaneous Isolation of Principal Central Nervous System-Resident Cell Types from Adult Autoimmune Encephalomyelitis Mice

Published on: October 6, 2023

  • Immune complexes were deposited in the livers and kidneys of sirt1-null mice.
  • Some sirt1-null mice developed a diabetes insipidus-like disease near 2 years of age.

    • Conclusions:

    • SIRT1 plays a role in maintaining normal immune function.
    • Loss of SIRT1 function is associated with the development of autoimmune phenomena.
    • SIRT1 may delay the onset of autoimmune diseases.