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Updated: Jul 3, 2026

The Immediate Partial Removal of Cumulus-Oocyte Complexes: A Refined Approach for Rapid Observation of In Vitro Fertilization
Published on: October 18, 2024
Clomifene citrate or unstimulated intrauterine insemination compared with expectant management for unexplained
S Bhattacharya1, K Harrild, J Mollison
1Department of Obstetrics and Gynaecology, University of Aberdeen, Aberdeen AB25 2ZD. s.bhattacharya@abdn.ac.uk
Objective:
To compare the effectiveness of clomifene citrate and unstimulated intrauterine insemination with expectant management for the treatment of unexplained infertility.
Design:
Three arm parallel group, pragmatic randomised controlled trial.
Setting:
Four teaching hospitals and a district general hospital in Scotland.
Participants:
Couples with infertility for over two years, confirmed ovulation, patent fallopian tubes, and motile sperm.
Intervention:
Expectant management, oral clomifene citrate, and unstimulated intrauterine insemination.
Main Outcome Measures:
The primary outcome was live birth. Secondary outcome measures included clinical pregnancy, multiple pregnancy, miscarriage, and acceptability.
Results:
580 women were randomised to expectant management (n=193), oral clomifene citrate (n=194), or unstimulated intrauterine insemination (n=193) for six months. The three randomised groups were comparable in terms of age, body mass index, duration of infertility, sperm concentration, and motility. Live birth rates were 32/193 (17%), 26/192 (14%), and 43/191 (23%), respectively. Compared with expectant management, the odds ratio for a live birth was 0.79 (95% confidence interval 0.45 to 1.38) after clomifene citrate and 1.46 (0.88 to 2.43) after unstimulated intrauterine insemination. More women randomised to clomifene citrate (159/170, 94%) and unstimulated intrauterine insemination (155/162, 96%) found the process of treatment acceptable than those randomised to expectant management (123/153, 80%) (P=0.001 and P<0.001, respectively).
Conclusion:
In couples with unexplained infertility existing treatments such as empirical clomifene and unstimulated intrauterine insemination are unlikely to offer superior live birth rates compared with expectant management.
Trial Registration:
ISRCT No: 71762042.
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