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Related Concept Videos

DNA Packaging00:58

DNA Packaging

Overview
DNA Packaging00:58

DNA Packaging

Overview
Chromatin Packaging01:32

Chromatin Packaging

Each human somatic cell contains 6 billion base pairs of DNA. Each base pair is 0.34 nm long, meaning each diploid cell contains a staggering 2 meters of DNA. This long DNA strand is packed inside a nucleus measuring only 10-20 microns in diameter with the help of specialized DNA-binding proteins called histones. Together they form a compact DNA-protein complex called chromatin. The chromatin is further compacted into higher-order structures. The highest level of compaction is achieved during...
Chromatin Packaging02:21

Chromatin Packaging

Each human somatic cell contains 6 billion base-pairs of DNA. Each base-pair is 0.34 nm long, which means that each diploid cell contains a staggering 2 meters of DNA. How is such a long DNA strand packed inside a nucleus measuring only 10 - 20 microns in diameter? 
The chromatin
In combination with specialized DNA binding protein called Histones, the DNA double helix forms a compact DNA: protein complex called chromatin. The chromatin itself is further compacted into higher-order structures.
Genomic DNA in Eukaryotes00:58

Genomic DNA in Eukaryotes

Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
PCR01:32

PCR

Overview

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Related Experiment Video

Updated: Jul 3, 2026

DNA Nanotubes as a Versatile Tool to Study Semiflexible Polymers
08:00

DNA Nanotubes as a Versatile Tool to Study Semiflexible Polymers

Published on: October 25, 2017

Programming DNA tube circumferences.

Peng Yin1, Rizal F Hariadi, Sudheer Sahu

  • 1Department of Computer Science, California Institute of Technology, Pasadena, CA 91125, USA. py@caltech.edu

Science (New York, N.Y.)
|August 9, 2008
PubMed
Summary
This summary is machine-generated.

Researchers created DNA-based molecular tubes with precise, tunable sizes. This DNA nanotechnology breakthrough enables the programmable self-assembly of custom-shaped nanostructures for advanced materials science applications.

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Last Updated: Jul 3, 2026

DNA Nanotubes as a Versatile Tool to Study Semiflexible Polymers
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Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
10:23

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

Area of Science:

  • Nanotechnology
  • Materials Science
  • Supramolecular Chemistry

Background:

  • Synthesizing molecular tubes with controlled circumferences is a key challenge in nanotechnology and materials science.
  • Achieving monodispersity in molecular tube dimensions is crucial for predictable material properties.

Purpose of the Study:

  • To develop a method for programming and synthesizing molecular tubes with user-defined, monodisperse circumferences.
  • To demonstrate the self-assembly of DNA-based molecular tubes with a range of precisely controlled sizes.

Main Methods:

  • Utilizing a 42-base single-stranded DNA motif with modular domains.
  • Programming tube circumference by defining specific complementarity relationships between DNA domains.
  • Employing a single-step annealing process for self-assembly.

Main Results:

  • Successfully synthesized long molecular tubes via self-assembly.
  • Demonstrated precise control over tube circumference, achieving monodisperse sizes of 4, 5, 6, 7, 8, 10, and 20 DNA helices.
  • The DNA motif design directly dictates the resulting tube circumference.

Conclusions:

  • A novel method for programming molecular tube circumferences using DNA motifs has been established.
  • Single-step annealing provides an efficient route to self-assemble monodisperse molecular tubes.
  • This work advances the design and synthesis of programmable nanostructures for diverse applications.