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Thrombospondin-2 modulates extracellular matrix remodeling during physiological angiogenesis

Marie M Krady1, Jianmin Zeng, Jun Yu

  • 1Department of Pathology, Yale University School of Medicine, New Haven, CT 06536-9812, USA.

The American Journal of Pathology
|August 9, 2008
PubMed
Summary

Thrombospondin 2 (TSP2) inhibits new blood vessel formation (angiogenesis) by altering the extracellular matrix and matrix metalloproteinases (MMPs). TSP2 deficiency accelerates blood flow recovery and enhances vascular networks in mice.

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