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[Clinical features of severe infant atopic dermatitis with hypoproteinemia]

Masayuki Akashi1, Ichiro Nomura, Akemi Saito

  • 1Division of Allergy, National Center for Child Health and Development.

Arerugi = [Allergy]
|August 9, 2008
PubMed

Insights

Severe infant atopic dermatitis (AD) can cause hypoproteinemia, growth impairment, and electrolyte issues. Prompt treatment with skincare, topical steroids, and allergen removal effectively improves symptoms and lab findings in these patients.

Area of Science:

  • Pediatric Dermatology
  • Clinical Immunology

Context:

  • Severe atopic dermatitis (AD) in infants can present with serious complications.
  • Hypoproteinemia and growth impairment have been sporadically reported in infants with severe AD.

Purpose:

  • To characterize initial clinical findings of infants with severe atopic dermatitis (AD) and hypoproteinemia.
  • To analyze the treatment course and outcomes for these patients.

Summary:

  • A study of 119 infants with AD identified 15 cases of severe AD with hypoproteinemia.
  • These infants exhibited growth impairment (height/weight < 3rd percentile), electrolyte abnormalities (hyponatremia/hyperpotassemia), and thrombocytosis.
  • Treatment involving skincare, topical steroids, and allergen avoidance led to rapid improvement in symptoms and laboratory markers.

Impact:

  • Highlights the potential systemic complications of severe infant AD, including hypoproteinemia, growth issues, electrolyte imbalances, and thrombocytosis.
  • Demonstrates that appropriate and timely treatment can effectively manage these severe manifestations of atopic dermatitis.
Abstract

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