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Recurrent Fisher's syndrome with immunological abnormalities and replicated laterality
T Uchihara1, M Ikeda, H Tsukagoshi
1Department of Neurology, Asahi General Hospital, Chiba, Japan.
European Neurology
|January 1, 1991
Summary
Fisher's syndrome recurred after 10 years, with similar cranial nerve findings. This suggests localized immune sensitization may cause recurrence in Fisher's syndrome, similar to Guillain-Barré syndrome.
Area of Science:
- Neurology
- Immunology
Background:
- Fisher's syndrome is a rare neurological disorder.
- Recurrence of Fisher's syndrome is uncommon, especially after a decade.
Observation:
- A patient experienced a recurrence of Fisher's syndrome 10 years after the initial episode.
- The cranial nerve deficits observed during the recurrence mirrored the laterality seen in the first episode.
Findings:
- The recurrence demonstrated a consistent pattern of neurological involvement, suggesting a persistent underlying mechanism.
- Immunological markers, including an increased CD4/CD8 ratio and elevated IgE levels, were observed.
- These immunological findings suggest Fisher's syndrome shares similarities with Guillain-Barré syndrome.
Implications:
- Localized immune sensitization is hypothesized to be responsible for the reproducible laterality in recurrent Fisher's syndrome.
- The immunological profile indicates a shared pathophysiology between Fisher's syndrome and Guillain-Barré syndrome.
- Further research into the immunological aspects of Fisher's syndrome is warranted to understand recurrence patterns and develop targeted therapies.