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N-methyl-D-aspartate receptor antagonists have variable affect in 3-nitropropionic acid toxicity

Payman Nasr1, Timothy Carbery, James W Geddes

  • 1Department of Biological Sciences, Kent State University, Ashtabula, OH 44004, USA. pnasr@kent.edu

Neurochemical Research
|August 9, 2008
PubMed
Summary

NMDA receptor antagonists show mixed effects on 3-nitropropionic acid (3NP) neurotoxicity. Memantine delayed striatal damage but did not improve motor deficits, while ifenprodil worsened them, cautioning against their use in metabolic neurodegenerative disorders.

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