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Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
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Pharmacodynamics in Geriatric Patients: Effects of Age01:27

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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Aging01:26

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Updated: May 1, 2026

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
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Aging and human performance.

Neil Charness1

  • 1Psychology Department, Florida State University, Tallahassee, Florida 32306-4301, USA. charness@psy.fsu.edu

Human Factors
|August 12, 2008
PubMed
Summary
This summary is machine-generated.

Human factors research, particularly in the 1990s, has advanced understanding of aging and human performance. Design and training interventions can improve older adults' quality of life and performance.

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Area of Science:

  • Human Factors
  • Gerontology
  • Ergonomics

Background:

  • Global populations are aging, necessitating research into age-related performance changes.
  • Experimental manipulation of age is not feasible, requiring advanced theoretical and modeling approaches for valid inferences.

Purpose of the Study:

  • To identify key theoretical and practical contributions to aging and human performance in the journal Human Factors.
  • To analyze trends and impactful research in the field of aging and human performance.

Main Methods:

  • Citation analysis of articles in Human Factors related to age or aging.
  • Ranking articles based on citation impact to identify influential research.

Main Results:

  • Publication rates on aging increased significantly, especially in the 1990s, following special issues.
  • Highly cited articles predominantly focus on the intersection of age and driving performance.

Conclusions:

  • Applied research emphasizes improved performance measurement, simulation, and modeling.
  • Environmental design supporting declining abilities and targeted training are effective interventions for older adults.
  • Human factors specialists can enhance the quality of life for an aging population through improved design and support.