Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Mania and Antimanic Drugs: Overview01:24

Mania and Antimanic Drugs: Overview

Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as a...
Theoretical Approaches to Psychological Disorder01:29

Theoretical Approaches to Psychological Disorder

The development of psychological disorders, which are characterized by deviant, maladaptive, and personally distressing behaviors, has been explored through several theoretical approaches.
Biological approach
The biological approach posits that internal, organic factors are the primary causes of such disorders. This perspective emphasizes brain structure and function, genetic predispositions, and neurotransmitter imbalances. For example, schizophrenia has been associated with both genetic...
Diagnostic and Statistical Manual of Mental Disorders (DSM)01:27

Diagnostic and Statistical Manual of Mental Disorders (DSM)

The Diagnostic and Statistical Manual of Mental Disorders (DSM) serves as the primary classification system for mental health disorders, providing standardized diagnostic criteria for clinicians and researchers. First published by the American Psychiatric Association (APA) in 1952, the DSM has undergone several revisions to reflect evolving psychiatric understanding. The fifth edition, DSM-5, released in 2013, introduced key updates that expanded diagnostic categories and modified diagnostic...
Bipolar Disorder01:30

Bipolar Disorder

Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hypomania-Checklist-33: risk stratification and factor structure in a mixed psychiatric adolescent sample.

International journal of bipolar disorders·2024
Same author

Outcomes of electroconvulsive therapy in patients with depressive symptoms with versus without comorbid personality disorders/traits: A systematic review and meta-analysis.

Acta psychiatrica Scandinavica·2023
Same author

The role of affective temperaments in bipolar disorder: The solid role of the cyclothymic, the contentious role of the hyperthymic, and the neglected role of the irritable temperaments.

European psychiatry : the journal of the Association of European Psychiatrists·2023
Same author

Clinical research diagnostic criteria for bipolar illness (CRDC-BP): rationale and validity.

International journal of bipolar disorders·2022
Same author

Validation of the 33-Item Hypomania Checklist-External Assessment in Screening Adolescents for Bipolar Disorder.

Frontiers in psychiatry·2022
Same author

Longitudinal reciprocal associations between depression, anxiety, and substance use disorders over three decades of life.

Journal of affective disorders·2022
Same journal

Mapping topological abnormalities in cortical similarity networks to schizophrenia-associated gene expression.

Dialogues in clinical neuroscience·2026
Same journal

Poor sleep quality correlates with axial symptoms and mood problems in Parkinson's disease.

Dialogues in clinical neuroscience·2026
Same journal

Treatment of posttraumatic stress disorder (PTSD).

Dialogues in clinical neuroscience·2026
Same journal

Comparisons of thalamocortical functional connectivity in transgender women and cisgender individuals: associations with cognition in a Chinese cohort.

Dialogues in clinical neuroscience·2026
Same journal

The Arabic Generalized Anxiety Disorder 2 (GAD-2): Psychometric evaluation among mothers of children with intellectual disabilities.

Dialogues in clinical neuroscience·2026
Same journal

Polarisation of brain dynamics in mania and depression.

Dialogues in clinical neuroscience·2026
See all related articles

Related Experiment Video

Updated: Jun 21, 2026

Event Related Potentials (ERPs) and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder (ADHD)
10:02

Event Related Potentials (ERPs) and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder (ADHD)

Published on: March 12, 2020

Bipolar disorder--methodological problems and future perspectives.

Jules Angst1

  • 1Zurich University, Psychiatric Hospital, Research Department, Zurich, Switzerland. jangst@bli.uzh.ch

Dialogues in Clinical Neuroscience
|August 12, 2008
PubMed
Summary
This summary is machine-generated.

Bipolar disorder (BPD) is a serious mood disorder often misdiagnosed as major depressive disorder (MDD) due to unclear definitions. A dimensional approach and early recognition are crucial for timely intervention and prevention.

More Related Videos

Closed-Loop Neurostimulation for Biomarker-Driven, Personalized Treatment of Major Depressive Disorder
05:19

Closed-Loop Neurostimulation for Biomarker-Driven, Personalized Treatment of Major Depressive Disorder

Published on: July 7, 2023

Developing a Rat Model for Bipolar Disorder
04:42

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

Related Experiment Videos

Last Updated: Jun 21, 2026

Event Related Potentials (ERPs) and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder (ADHD)
10:02

Event Related Potentials (ERPs) and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder (ADHD)

Published on: March 12, 2020

Closed-Loop Neurostimulation for Biomarker-Driven, Personalized Treatment of Major Depressive Disorder
05:19

Closed-Loop Neurostimulation for Biomarker-Driven, Personalized Treatment of Major Depressive Disorder

Published on: July 7, 2023

Developing a Rat Model for Bipolar Disorder
04:42

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

Area of Science:

  • Psychiatry
  • Mood Disorders Research

Background:

  • Bipolar disorder (BPD) is a significant mood disorder with high recurrence, comorbidity, and mortality rates.
  • Current diagnostic definitions for BPD in adults and children are inadequate, leading to overdiagnosis of major depressive disorder (MDD).
  • Biological research on BPD is hampered by these imprecise definitions.

Purpose of the Study:

  • To address the challenges in defining and diagnosing bipolar disorder.
  • To recommend improved diagnostic approaches for BPD.
  • To highlight the importance of early recognition and intervention in BPD.

Main Methods:

  • Review of current clinical concepts and diagnostic definitions of bipolar disorder.
  • Proposal of a dimensional approach for quantifying hypomania, depression, and anxiety using self-assessment and symptom checklists.
  • Discussion of strategies for early recognition of BPD onset, particularly in adolescents.

Main Results:

  • Current definitions of BPD are unsatisfactory and contribute to misdiagnosis.
  • A dimensional, quantitative approach is recommended to improve diagnostic accuracy.
  • Early identification of BPD correlates in childhood and adolescence is essential.

Conclusions:

  • Revised clinical concepts are needed for accurate BPD diagnosis and treatment.
  • A dimensional assessment strategy can enhance the identification of bipolarity.
  • Timely diagnosis and intervention are critical for secondary prevention of BPD.