Related Experiment Video
Updated: Jul 2, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Oxidized low-density lipoprotein and oxidative stress in the development of glomerulosclerosis
Hyun Soon Lee1, Chi Young Song
1Department of Pathology, Seoul National University College of Medicine, Seoul, Korea. hyunsoon@plaza.snu.ac.kr
Abstract:
Glomerulosclerosis frequently complicates most renal diseases and is characterized by mesangial matrix accumulation. Oxidized low-density lipoprotein (Ox-LDL) could induce oxidative stress and profibrotic gene expression in mesangial cells. This article will review our current understanding of the pathogenetic mechanisms of lipid-mediated glomerulosclerosis, emphasizing the fibrogenic signaling cascades triggered by Ox-LDL. In addition, therapeutic strategies to prevent the development of Ox-LDL-mediated glomerulosclerosis will be discussed.
More Related Videos
03:35Rapid Quantification of Oxidized and Reduced Forms of Glutathione Using Ortho -phthalaldehyde in Cultured Mammalian Cells In Vitro
Published on: June 28, 2024
14:25Quantification of Reactive Oxygen Species Using 2′,7′-Dichlorofluorescein Diacetate Probe and Flow-Cytometry in Müller Glial Cells
Published on: May 13, 2022
Related Concept Videos
Coronary Artery Disease II: Pathophysiology
Diabetic Nephropathy
Atherosclerosis I: Introduction
Coronary Artery Disease I: Introduction
Renal Corpuscle
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation