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Corrected thrombolysis in myocardial infarction frame counts in diabetic patients with angiographically normal
Sedat Turkoglu1, Murat Ozdemir, Gulten Tacoy
1Department of Cardiology, Gazi University School of Medicine, Ankara, Turkey. turkoglusedat@gmail.com
Insights
Corrected thrombolysis in myocardial infarction (TIMI) frame count (CTFC) did not differ between diabetic and non-diabetic patients with normal coronary arteries. This suggests CTFC may be inadequate for detecting microvascular dysfunction in diabetic individuals with normal coronary angiograms.
Area of Science:
- Cardiology
- Diabetology
- Vascular Medicine
Background:
- Diabetes mellitus is associated with microvascular dysfunction.
- Assessing microvascular function in diabetic patients with normal coronary arteries is clinically important.
- Corrected thrombolysis in myocardial infarction (TIMI) frame count (CTFC) is a method to evaluate coronary microvascular function.
Purpose of the Study:
- To evaluate CTFC in patients with angiographically normal coronary arteries and diabetes mellitus.
- To determine if diabetes impacts microvascular function as measured by CTFC in this patient group.
Main Methods:
- A retrospective study of patients undergoing coronary angiography between 2000 and 2005.
- CTFC was calculated for the left anterior descending, left circumflex, and right coronary arteries.
- Comparison of CTFC between 118 diabetic and 122 non-diabetic patients with normal coronary angiograms.
Main Results:
- Mean CTFC values for LAD, Cx, and RCA were similar between diabetic and non-diabetic groups (p>0.05 for all).
- Stepwise multivariate linear regression identified body surface area as significantly correlated with CTFC in all three coronary arteries.
- No significant difference in microvascular function, as assessed by CTFC, was observed between the groups.
Conclusions:
- CTFC is similar in diabetic and non-diabetic patients with angiographically normal coronary arteries.
- The findings suggest CTFC may be insufficient for predicting microvascular disease in diabetic patients with normal coronary angiograms.
- Further research may be needed to identify more sensitive markers of microvascular dysfunction in this population.
Objective:
To evaluate corrected thrombolysis in myocardial infarction (TIMI) frame count (CTFC) in patients with angiographically normal coronary arteries and diabetes mellitus, a condition known to be associated with microvascular dysfunction.
Methods:
Patients who underwent coronary angiography in Gazi University Hospital, Ankara, Turkey between January 2000 and January 2005 were studied. Corrected TIMI frame count was calculated over the left anterior descending (LAD), left circumflex (Cx) and right coronary arteries (RCA) in 118 diabetic and 122 non-diabetic patients with normal coronary angiogram.
Results:
The mean CTFC values of the LAD, Cx, and the RCA were similar in diabetics and nondiabetics 21.0 +/= 7.5 versus 21.3 +/= 9.6, 23.3 +/= 9.7 versus 23.5 +/= 10.8, 17.9 +/= 6.7 versus 18.7 +/=7.4 respectively, p>0.05 for all comparisons. In stepwise multivariate linear regression analysis, body surface area had a significant correlation with CTFC of all the 3 coronary arteries.
Conclusion:
We conclude that CTFC in diabetics and non-diabetics with angiographically normal coronary arteries is similar. Since microvascular disease is an inherent component of diabetes, our finding may reflect the inadequacy of CTFC in predicting microvascular disease in diabetic patients with normal coronary angiograms.
