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Related Experiment Video

Updated: Jul 2, 2026

Behavioral and Locomotor Measurements Using an Open Field Activity Monitoring System for Skeletal Muscle Diseases

Behavioral and Locomotor Measurements Using an Open Field Activity Monitoring System for Skeletal Muscle Diseases

Published on: September 29, 2014

Macrodystrophia lipomatosa with syndactyly.

Waleed S Mahafza¹, Azmi A Haroun, Ahmed D Abdul-Wahab

¹Department of Radiology, Jordan University Hospital, Amman, Jordan. wmahafza@hotmail.com

Saudi Medical Journal

|August 12, 2008

Summary

Macrodystrophia lipomatosa (MDL) with syndactyly is a rare congenital gigantism. This case highlights characteristic imaging findings to differentiate it from other localized gigantism causes.

Area of Science:

Medical imaging
Orthopedics
Genetics

Background:

Macrodystrophia lipomatosa (MDL) is a rare congenital condition causing localized gigantism.
It involves hypertrophy of mesenchymal tissues, notably adipose tissue, in affected digits.
Syndactyly, or fused digits, is an uncommon but recognized association with MDL.

Observation:

This report details a unique case of MDL affecting the hand.
The case presented with the rare co-occurrence of syndactyly.
Clinical presentation included significant digital overgrowth and fusion.

Findings:

Radiographic and Magnetic Resonance Imaging (MRI) were crucial in diagnosis.
Imaging revealed characteristic patterns of adipose tissue overgrowth and osseous hypertrophy.

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Specific findings helped distinguish this case from other forms of localized gigantism.

Implications:

Accurate diagnosis of MDL with syndactyly is essential for appropriate management.
Understanding imaging findings aids in differentiating MDL from other gigantism etiologies.
This case contributes to the literature on rare congenital hand anomalies.