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Extracellular Vesicle Tissue Factor Activity Assay
Published on: December 29, 2023
Elevated plasma fibronectin levels associated with venous thromboembolism.
Natalie M Pecheniuk1, Darlene J Elias, Hiroshi Deguchi
1Department of Molecular and Experimental Medicine (MEM-180), The Scripps Research Institute, La Jolla, CA 92037, USA.
Thrombosis and Haemostasis
|August 12, 2008
Summary
High plasma fibronectin levels are linked to an increased risk of venous thromboembolism (VTE), particularly in males. This finding suggests fibronectin may be a useful biomarker for VTE risk assessment.
Area of Science:
- Cardiovascular Science
- Hematology
- Biomarker Discovery
Background:
- Elevated plasma fibronectin is observed in various conditions, including arterial disease.
- Atherothrombosis and venous thromboembolism (VTE) share common risk factors, suggesting overlappingpathogenic mechanisms.
- Fibronectin's role as a potential biomarker in VTE requires further investigation.
Purpose of the Study:
- To investigate the association between elevated plasma fibronectin levels and the risk of developing VTE.
- To compare plasma fibronectin concentrations in VTE cases versus matched controls.
- To explore potential differences in this association based on VTE etiology (idiopathic vs. secondary) and patient demographics (sex).
Main Methods:
- A case-control study was conducted using data from the Scripps Venous Thrombosis Registry.
- Plasma fibronectin levels were measured in 113 VTE cases and age- and sex-matched controls.
- Statistical analyses, including odds ratios (OR) and adjustments for covariates (sex, age, BMI, Factor V Leiden, prothrombin nt20210A), were performed.
Main Results:
- VTE cases exhibited significantly higher mean plasma fibronectin concentrations (127%) compared to controls (103%).
- The association between high fibronectin levels and VTE remained significant after adjusting for multiple risk factors (OR = 7.60).
- Elevated fibronectin was particularly associated with idiopathic VTE and showed a stronger association in the male cohort.
Conclusions:
- Elevated plasma fibronectin levels are significantly associated with an increased risk of VTE.
- Plasma fibronectin may serve as a valuable biomarker for identifying individuals at higher risk for VTE, especially males.
- These findings reinforce the link between biomarkers and risk factors for both arterial atherothrombosis and VTE.
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