Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 2, 2026

Intracranial Cannula Implantation for Serial Locoregional Chimeric Antigen Receptor (CAR) T Cell Infusions in Mice
05:22

Intracranial Cannula Implantation for Serial Locoregional Chimeric Antigen Receptor (CAR) T Cell Infusions in Mice

Published on: February 24, 2023

Local chemotherapy in the rat brainstem with multiple catheters: a feasibility study.

U W Thomale1, B Tyler, V M Renard

  • 1Selbständiger Arbeitsbereich Pädiatrische Neurochirurgie, Charité, Campus Virchow Klinikum, Universitätsmedizin Berlin, Augustenburgr Platz 1, 13353, Berlin, Germany. uthomale@charite.de

Child'S Nervous System : Chns : Official Journal of the International Society for Pediatric Neurosurgery
|August 12, 2008
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Shunt-related cerebrospinal fluid overdrainage - a multicentre consensus definition.

Acta neurochirurgica·2026
Same author

The state of targeted therapeutic pharmacological approaches in pediatric neurosurgery: report from the European Society for Pediatric Neurosurgery (ESPN) Consensus Conference 2024.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery·2025
Same author

Retrospective single-center historical comparative study between proGAV and proGAV2.0 for surgical revision and implant duration.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery·2022
Same author

TROPHY registry - status report.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery·2021
Same author

Integrated understanding of hydrocephalus - a practical approach for a complex disease.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery·2021
Same author

Neuroendoscopic lavage for the treatment of CSF infection with hydrocephalus in children.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery·2018

Local chemotherapy delivery to the brainstem using convection-enhanced delivery (CED) is feasible in rats with multiple cannulas. However, carboplatin caused neurological deficits, highlighting the need for less toxic drugs in brainstem CED.

Area of Science:

  • Neurosurgery
  • Oncology
  • Pharmacology

Background:

  • Brainstem gliomas are challenging to treat due to the critical location and limited therapeutic options.
  • Convection-enhanced delivery (CED) offers a potential route for localized chemotherapy in the brainstem.
  • Technical feasibility of multi-cannula CED in the brainstem requires investigation.

Purpose of the Study:

  • To assess the feasibility of multiple cannula placements in the rat brainstem for convection-enhanced delivery (CED).
  • To evaluate drug distribution and local tissue effects of carboplatin delivered via CED in the brainstem.
  • To determine the safety and neurological impact of multi-cannula CED in a rat model.

Main Methods:

  • 38 male Fisher rats underwent stereotactic placement of one to three cannulas in the brainstem.

More Related Videos

Catheterization of the Carotid Artery and Jugular Vein to Perform Hemodynamic Measures, Infusions and Blood Sampling in a Conscious Rat Model
09:05

Catheterization of the Carotid Artery and Jugular Vein to Perform Hemodynamic Measures, Infusions and Blood Sampling in a Conscious Rat Model

Published on: January 30, 2015

Related Experiment Videos

Last Updated: Jul 2, 2026

Intracranial Cannula Implantation for Serial Locoregional Chimeric Antigen Receptor (CAR) T Cell Infusions in Mice
05:22

Intracranial Cannula Implantation for Serial Locoregional Chimeric Antigen Receptor (CAR) T Cell Infusions in Mice

Published on: February 24, 2023

Catheterization of the Carotid Artery and Jugular Vein to Perform Hemodynamic Measures, Infusions and Blood Sampling in a Conscious Rat Model
09:05

Catheterization of the Carotid Artery and Jugular Vein to Perform Hemodynamic Measures, Infusions and Blood Sampling in a Conscious Rat Model

Published on: January 30, 2015

  • Carboplatin or vehicle was delivered over 7 days using Alzet pumps at a rate of 1 microl/h.
  • Neurological function, drug distribution (platinum concentration), and histological changes were assessed.

    • Main Results:

    • Multi-cannula placement in the rat brainstem was technically feasible.
    • Carboplatin delivery resulted in persistent neurological deficits, unlike vehicle delivery.
    • Drug distribution was more homogeneous with three cannulas compared to one or two.
    • Histological examination revealed localized edema at cannula insertion sites.

    Conclusions:

    • Unilateral placement of up to three cannulas in the rat brainstem for local drug delivery is feasible.
    • The observed neurological deficits with carboplatin underscore the necessity of using low-toxicity agents for CED in the brainstem.