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Related Experiment Video

Updated: Jul 2, 2026

Left Anterior Descending Coronary Artery Ligation for Ischemia-Reperfusion Research: Model Improvement via Technical Modifications and Quality Control

Left Anterior Descending Coronary Artery Ligation for Ischemia-Reperfusion Research: Model Improvement via Technical Modifications and Quality Control

Published on: December 16, 2022

A meta-analysis update: percutaneous coronary interventions.

William T Cecil¹, Panagiotis Kasteridis, John W Barnes

¹BlueCross BlueShield of Tennessee, 801 Pine St, 1E, Chattanooga, TN 37402, USA. bill_cecil@bcbst.com

The American Journal of Managed Care

|August 12, 2008

Summary

This summary is machine-generated.

Percutaneous coronary interventions (PCIs) show no benefit over medical therapy (MT) for stable coronary artery disease (CAD) mortality. Recent trials confirm PCIs increase risks of cardiac death, myocardial infarction (MI), and nonfatal MI compared to MT alone.

Related Experiment Videos

Last Updated: Jul 2, 2026

Left Anterior Descending Coronary Artery Ligation for Ischemia-Reperfusion Research: Model Improvement via Technical Modifications and Quality Control

Left Anterior Descending Coronary Artery Ligation for Ischemia-Reperfusion Research: Model Improvement via Technical Modifications and Quality Control

Published on: December 16, 2022

Area of Science:

Cardiology
Interventional Cardiology
Evidence Synthesis

Background:

Stable coronary artery disease (CAD) management involves balancing revascularization with medical therapy (MT).
Previous meta-analyses have evaluated percutaneous coronary interventions (PCIs) versus MT, with evolving evidence.
The optimal treatment strategy for stable CAD remains a focus of clinical research.

Purpose of the Study:

To update the comparative effectiveness of PCIs versus MT in stable CAD.
To incorporate data from two recent large randomized controlled trials (RCTs).
To reassess the risks and benefits of PCIs in stable CAD.

Main Methods:

Updated meta-analysis of eleven previously included RCTs and two new RCTs.
Application of fixed-effects and random-effects models for summary estimates.
Assessment of statistical heterogeneity and bias, including cumulative and influence analyses.

Main Results:

No significant difference in mortality risk between PCIs and MT alone.
PCIs associated with a 12% increased risk of cardiac death or myocardial infarction (MI).
PCIs associated with a 22% increased risk of nonfatal MI; cumulative analysis favors MT.

Conclusions:

Recent RCTs reinforce that PCIs offer no marginal benefit over MT for mortality in stable CAD.
Evidence suggests PCIs increase the risk of cardiac death/MI and nonfatal MI compared to MT.
Conclusions regarding PCI for preventing subsequent procedures remain uncertain due to study heterogeneity.