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Published on: January 20, 2019
Novel epigenetic targets in lymphoproliferative disorders
1Servei d'Hematologia Clinica, Hospital de la Santa Creu i Sant Pau, Sant Antoni Maria Claret 167, 08025 Barcelona, Spain. jdelgadog@santpau.cat
Current Cancer Drug Targets
|August 12, 2008
Summary
Epigenetic alterations, including DNA methylation and histone acetylation changes, significantly contribute to hematological malignancies. Understanding these epigenetic changes in lymphoma offers new diagnostic and therapeutic strategies.
Area of Science:
- Hematology
- Oncology
- Molecular Biology
Background:
- Genetic abnormalities are established drivers of hematological malignancies.
- Epigenetic alterations, specifically in DNA methylation and histone acetylation, also play a critical role in cancer development.
- These epigenetic changes are notably altered in both myeloid and lymphoid tumors.
Purpose of the Study:
- To review key epigenetic alterations in lymphoma-derived cell lines and primary lymphoid tumors.
- To explore the potential of pharmacologic manipulation of these epigenetic abnormalities for clinical treatment.
Main Methods:
- Review of recent advances in understanding epigenetic mechanisms in normal and malignant lymphoid cells.
- Analysis of epigenetic alterations in lymphoma models and patient samples.
Main Results:
- Significant alterations in DNA methylation and histone acetylation patterns are observed in lymphoid tumors.
- These epigenetic changes impact gene expression critical for lymphoma development and progression.
Conclusions:
- Epigenetic alterations are crucial in hematological malignancies, particularly lymphoma.
- Targeting these epigenetic abnormalities presents a promising avenue for novel diagnostic markers, prognostic classifications, and therapeutic interventions in clinical practice.
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